To complicate things further, glutamate has the ability to bind with six other receptors in the brain, like the NMDA receptor, which assists in delivering calcium to the cell and plays a vital role in memory function and synaptic plasticity. Calcium is used by glutamate as the agent that actually inflicts the harm on the cell. So, if there is an excess of calcium in the body for any reason, it too will contribute to the GABA and glutamate imbalance.
Glutamate and calcium together cause ongoing firing of the neurons, which triggers the release of inflammatory mediators, which leads to more influx of calcium. It becomes a vicious cycle that results in neural inflammation and cell death. Glutamate has been described as the gun, while calcium should be seen as the bullet, says Dr. Mark Neveu, a former president of the National Foundation of Alternative Medicine. It’s important to note that activation of the NMDA receptor also involves glycine, D-serine or D-alanine, which means either one of these could allow for more influx of calcium as well.
Magnesium will help regulate calcium levels and so can zinc. However, higher doses of zinc (more than 40mg per day) can also activate the release of glutamate through non-NMDA glutamate receptors, so one must exercise caution with zinc. However, if calcium is excessively high, other herbs or nutrients may be used to bring it down, like lithium orotate, Boswalia or wormwood. Lithium, as well as iodine and boron, can also assist in lowering glutamate. Calcium intake in food may need to be reduced or limited if calcium is too high. Magnesium is also able to bind to and activate GABA receptors.
If one exhibits low levels of calcium, Dr. Amy Yasko recommends using nettle or chamomile to increase calcium levels, rather than supplementation of calcium itself, if we are dealing with someone who has an imbalance in GABA and glutamate. Vitamin K & D would be important as well. If supplemental calcium is used it should be accompanied by magnesium, both in citrate form, which will help control the excitotoxin activity.
pffff je me demande combien de temps ça va encore prendre... je suis vraiment toute seule là dedans les médecins s'en foutent et je me sens mal tout le temps depuis si longtemps... je craque à des moments j'ai envie de me suicider
Caution Notice
The maximum dose of elemental calcium that should be taken at one time is 500 mg, to avoid unwanted effects on absorption of calcium and parathyroid hormone.[1]
Reported adverse effects of calcium use include constipation, excessive abdominal cramping, bloating, severe diarrhea, and abdominal pain.[2]
Additionally, high serum calcium levels, also known as hypercalcemia, has been associated with an increased risk of cardiovascular events, myocardial infarction, and stroke.[3][4][5]
Avis de mise en garde
La dose maximale de calcium élémentaire qui doit être pris en une seule fois est de 500 mg, pour éviter les effets indésirables sur l'absorption du calcium et l'hormone parathyroïdienne. [1]
effets indésirables rapportés d'utilisation du calcium, notamment la constipation, des crampes abdominales excessive, des ballonnements, des diarrhées sévères et des douleurs abdominales. [2]
En outre, les niveaux de calcium sérique élevé, également connu sous le nom de l'hypercalcémie, a été associée à un risque accru d'événements cardiovasculaires, l'infarctus du myocarde, et d'AVC. [3] [4] [5]
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